6-fold increase of indinavir auc 24h , a 1.
Information about Indinavir.
Indinavir is metabolized by CYP3A4Drugs that induce CYP3A4 activity would be expected to increase the clearance of indinavirresulting in lowered plasma concentrations of indinavirCoadministration of CRIXIVAN and other drugs that inhibit CYP3A4 may decrease the clearance of indinavir and may result in increased plasma concentrations of indinavir.
Initiation of CRIXIVANa CYP3A inhibitorin patients receiving medications metabolized by CYP3A or initiation of medications metabolized by CYP3A in patients already receiving CRIXIVANmay increase plasma concentrations of medications metabolized by CYP3AInitiation of medications that inhibit or induce CYP3A may increase or decrease concentrations of CRIXIVANrespectivelyThese interactions may lead to:
Patients should be advised to avoid doing things that can spread HIV-1 infection to others.
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based on in vitro data in human liver microsomes, indinavir does not inhibit cyp1a2, cyp2c9, cyp2e1 and cyp2b6.