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The purpose of this study is to determine whether baricitinib therapy alone is noninferior to methotrexate mtx therapy alone in in the treatment of moderate to severe active rheumatoid arthritis ra .

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Methotrexate, because of evidence of potential teratogencity should be stopped in men and women planning conception see above .

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Methotrexate may make you feel drowsy or dizzy, therefore you may be advised not to drive or operate machinery if you do not feel well.

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some times infusion of alkaline fluid may be used with methotrexate treatment in order to decrease the risk of renal toxicity.


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