Verapamil is a moderate cyp3a4 inhibitor and methylprednisolone is a cyp3a4 substrate.
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You may have more side effects from methylprednisolone if there is more breakdown of cyclosporine than of methylprednisolone.
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Consequently, when the dog s condition improves, the prednisolone shouldn t be discontinued immediately; the dog should still receive a decreased dose that will be lowered each week until it is safe to stop the treatment completely.
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depo-medrol sterile aqueous suspension contains methylprednisolone acetate which is the 6- methyl derivative of prednisolone.